This is an excerpt of Jura Health’s Chris Moore and UGenome’s Zachary Brooks Thought Leadership Article that appeared in MedCity News on July 29, 2025.
By leveraging select pharmacogenomic tools, physicians can minimize off-target effects of medications for their rare disease patients and support improved health outcomes while minimizing unintended consequences from adverse drug reactions or dosages.

During the pandemic, physician burnout rates skyrocketed to 62.8% in 2021 (Opens in a new window). Since, those numbers have dropped to below 50% (Opens in a new window), with varying reasons as to why. Despite the reduction in burnout, many physicians still report stress from administrative duties (Opens in a new window)and a shortage of physicians in their organization (Opens in a new window), both of which impede their work with patients.
Further, a recent Mayo Clinic study (Opens in a new window)noted that physician burnout rates remain alarmingly elevated compared to workers in other fields, causing concern. From workshops to conferences (Opens in a new window), the field is looking for opportunities to better support doctors so they can offer quality care to the patients they serve. Finding solutions soon matters, with a physician deficit in the United States of 86,000 anticipated by 2036 (Opens in a new window), according to the Association of American Medical Colleges. Though the need for more doctors impacts various areas of medicine, it holds specific implications for the field of rare diseases.
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