Husna Rahim, PharmD, RPh & Zachary S. Brooks, PhD
Integration of pharmacogenomic (PGx) data with nutritional genomics offers promising pathways for extending healthspan and promoting longevity
︎ Clinical implementation guidelines from CPIC and DPWG provide actionable frameworks for healthcare professionals to optimize medication selection
Specific single nucleotide polymorphisms (SNPs) directly influence aging processes in detoxification, antioxidant, and longevity genes like FOXO3, SOD2, and CYP1A2
The intersection of PGx and nutrigenomics presents unique opportunities to enhance longevity through personalized interventions. It enables healthcare professionals and individuals to optimize both pharmaceutical treatments and nutritional strategies based on individual genetic profiles, creating a foundation for promoting healthy aging and extended lifespan.
PGx deciphers how genetic variations influence individual drug responses. For example, if a patient is prescribed Warfarin, a blood thinner, and has a certain CYP2C9 variant causing slower metabolism of the drug, they may require a lower dose to prevent potentially fatal bleeding. International groups like the Clinical Pharmacogenetics Implementation Consortium (CPIC) create guidelines to help doctors and pharmacists translate genetic test results into clinically actionable insights (Shaman, 2024). As more PGx variants are discovered and their clinical applications known, using PGx testing to inform medication prescribing will become mainstay in the patient care continuum.
Nutrigenomics, similarly, investigates the relationship between genetics and diet, with the goal of tailoring nutrition plans to an individual’s unique DNA (Shaman, 2024). For example, key genetic variants in detoxification genes including SOD2, FOXO3, CYP1A2, and ADORA2A directly influence cellular protection mechanisms and can be enhanced by specific foods or supplements (Bonetti et al., 2023).
The integration of PGx and nutrigenomics holds immense promise for promoting healthy longevity. By understanding the interplay between our genes, food, and medicine, we can make more informed and effective health decisions (Zhang et al., 2020). The application of genomic technologies paves the way for a future where we can actively enhance both our healthspan and lifespan.
Bonetti G, et al. (2023) Nutrigenomics: SNPs correlated to detoxification, antioxidant capacity and longevity. Clin Ter.
Shaman JA. (2024) The Future of Pharmacogenomics: Integrating Epigenetics, Nutrigenomics, and Beyond. J Pers Med.
Zhang ZD, et al. (2020). Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat Metab.
Learn more about UGenome’s Personalized Medication Service, ProPEx, or contact UGenome. You can also find case studies for UGenome’s bioinformatics services Metabolite Identification, Bone Metastasis Risk Analysis in Breast Cancer, Survival Analysis with gene signatures in cancer
#ugenome, #ugenomeai, #genetics, #pharmacogenetics, #genomicmedicine, #sequencing, #datascience, #lifesciences, #bioinformatics, #biostatistics, #pharma, #bullpen, #NVIDIAInception, #foundershub